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Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are chronic inflammatory diseases with different clinical manifestations [4]. RA is characterized by inflammation, pain and stiffness in the joints, while SpA typically includes spine pain, enthesitis (inflammation of tendons or ligaments where they attach to bone), psoriasis-like skin lesions and uveitis [1][2]. Both conditions can lead to major adverse cardiovascular events such as stroke and myocardial infarction [5], but there may be differences in disease burden between RA, Psoriatic Arthritis (PsA) and axial SpA [3]. Ultrasound imaging has become increasingly important for identifying and differentiating between these conditions [6], while proteomic analysis of synovial fluid can help elucidate their aetiologies and pathogeneses[7].


[1]: Comparison of Clinical Manifestations in Rheumatoid Arthritis vs ... (https://pubmed.ncbi.nlm.nih.gov/34962619/)
[2]: SAT0385 CAN MISCLASSIFICATION BETWEEN ... (https://ard.bmj.com/content/79/Suppl_1/1141)
[3]: A Comparison of Disease Burden in Rheumatoid Arthritis, Psoriatic ... (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390320/)
[4]: Spondyloarthropathy and rheumatoid arthritis: two different diseases ... (https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-8-S1-P36)
[5]: Incidence and Prevalence of Major Adverse Cardiovascular Events ... (https://onlinelibrary.wiley.com/doi/abs/10.1002/acr.23567)
[6]: The importance of ultrasound in identifying and differentiating ... (https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-019-2050-4)
[7]: Proteomic analysis of synovial fluid from rheumatic arthritis and ... (https://clinicalproteomicsjournal.biomedcentral.com/articles/10.1186/s12014-020-09292-9)

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Rheumatoid arthritis (RA) is an autoimmune disorder that causes inflammation of the joints. It can affect any joint in the body, but most commonly affects the hands, wrists, and feet. Symptoms include pain, swelling, stiffness, and decreased range of motion. Treatment typically involves medications to reduce inflammation and slow disease progression as well as lifestyle modifications such as exercise and stress management.

Spondyloarthritis (SpA) is a type of inflammatory arthritis that primarily affects the spine and sacroiliac joints. It can also cause inflammation in other areas such as tendons or ligaments around the spine or peripheral joints like hips or shoulders. Symptoms may include back pain, stiffness, fatigue, enthesitis (inflammation at tendon/ligament attachments), psoriasis-like skin rash on elbows/knees/ankles/feet called spondyloarthropathy rash (SAR), eye irritation from uveitis or iritis ,and gastrointestinal issues from Crohn’s Disease or ulcerative colitis . Treatment typically includes anti-inflammatory medications to reduce symptoms along with physical therapy for stretching and strengthening exercises to improve mobility