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PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections) and PANS (Pediatric Acute-onset Neuropsychiatric Syndrome) are infection-triggered autoimmune disorders affecting the basal ganglia, which can result in a multitude of neuropsychiatric symptoms including obsessive compulsive disorder (OCD), anxiety, tics, decline in school performance, irritability and aggression [1][2][3][4][5]. The main difference between PANDAS and PANS is that PANDAS is linked to a strep infection while the cause of PANS is unknown [6][7]. Both conditions respond to similar treatments such as antibiotics or immunomodulatory therapies [8][9]. Diagnosis for both conditions requires careful evaluation by a medical professional [10].


[1]: NIMH » PANDAS—Questions and Answers (https://www.nimh.nih.gov/health/publications/pandas)
[2]: PANS | PANS: Pediatric Acute-onset Neuropsychiatric Syndrome ... (https://med.stanford.edu/pans.html)
[3]: What is PANS/PANDAS? | PPN (https://www.pandasppn.org/what-are-pans-pandas/)
[4]: PANDAS and PANS (for Parents) - Nemours KidsHealth (https://kidshealth.org/en/parents/pandas.html)
[5]: PANS and PANDAS have similar symptoms and respond to similar ... (https://www.moleculeralabs.com/pans-and-pandas-overview/)
[6]: Pediatric autoimmune neuropsychiatric disorders associated with ... (https://rarediseases.info.nih.gov/diseases/7312/pediatric-autoimmune-neuropsychiatric-disorders-associated-with-streptococcus-infections/)
[7]: Understanding PANDAS | PANDAS Network (https://pandasnetwork.org/understanding-pandas/)
[8]: PANDAS - Wikipedia (https://en.wikipedia.org/wiki/PANDAS)
[9]: Complete Guide to PANS and PANDAS - Child Mind Institute (https://childmind.org/guide/parents-guide-to-pans-and-pandas/)
[10]: PANDAS Syndrome: What It Is, Causes, Symptoms & Treatment (https://my.clevelandclinic.org/health/diseases/23553-pandas-syndrome)

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PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections) and PANS (Pediatric Acute-onset Neuropsychiatric Syndrome) are two related conditions that involve sudden onset of neuropsychiatric symptoms in children. Symptoms may include obsessive-compulsive disorder, tics, anxiety, depression, aggression, irritability and difficulty concentrating. These disorders are thought to be caused by an autoimmune reaction triggered by a streptococcal infection or other environmental triggers such as infections or stress. Treatment typically involves antibiotics for the underlying infection as well as medications to manage the psychiatric symptoms. Cognitive behavioral therapy is also recommended to help manage the psychological symptoms associated with these disorders.