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Non-celiac gluten sensitivity (NCGS) is a condition characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten [1]. Symptoms of NCGS are similar to those seen in celiac disease, but individuals with NCGS do not have the same antibodies or damage to their intestines as those with celiac disease [2]. The terms non-celiac gluten sensitivity (NCGS) and non-celiac wheat sensitivity (NCWS) are generally used to refer to this condition, when removing gluten from the diet results in symptom improvement [3]. It is believed that NCGS may be caused by an immune response triggered by gliadin, a component of gluten found in wheat, barley and rye [4][5]. Other potential causes include changes in gut microbiota or alterations in intestinal permeability due to dietary components other than gluten [6][7]. Gluten intolerance is also called non-celiac gluten sensitivity. It's not the same as celiac disease or a wheat allergy. About 6% of the U.S. population has some form of it[8], while only 1% has been diagnosed with celiac disease[9].


[1]: Recent advances in understanding non-celiac gluten sensitivity - PMC (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182669/)
[2]: Non-Celiac Gluten Sensitivity | BeyondCeliac.org (https://www.beyondceliac.org/celiac-disease/non-celiac-gluten-sensitivity/)
[3]: Non-Celiac Gluten/Wheat Sensitivity | Celiac Disease Foundation (https://celiac.org/about-celiac-disease/related-conditions/non-celiac-wheat-gluten-sensitivity/)
[4]: Nonceliac gluten sensitivity (https://pubmed.ncbi.nlm.nih.gov/25583468/)
[5]: Non-celiac gluten sensitivity - Wikipedia (https://en.wikipedia.org/wiki/Non-celiac_gluten_sensitivity)
[6]: Non-celiac wheat sensitivity: rationality and irrationality of a gluten ... (https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-020-01568-6)
[7]: Non-celiac gluten sensitivity - Harvard Health (https://www.health.harvard.edu/digestive-health/non-celiac-gluten-sensitivity)
[8]: Gluten Intolerance: Symptoms, Test, Non-Celiac Gluten Sensitivity (https://my.clevelandclinic.org/health/diseases/21622-gluten-intolerance)
[9]: Celiac Disease, Non-Celiac Gluten Sensitivity and Food Allergy (https://www.aaaai.org/tools-for-the-public/conditions-library/allergies/celiac-disease)

AI

Non-celiac gluten sensitivity (NCGS) is a condition in which people experience symptoms similar to those of celiac disease, but do not test positive for the antibodies associated with it. Symptoms may include abdominal pain, bloating, diarrhea, constipation, headaches and fatigue. Treatment involves following a strict gluten-free diet.