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Multiple system atrophy (MSA) is a rare, degenerative neurological disorder affecting the body's involuntary (autonomic) functions [1]. It is characterized by a combination of symptoms that affect both the autonomic nervous and motor systems [2]. Symptoms can include impairments to balance, coordination, bladder control, blood pressure regulation and breathing [3][4][5][6]. The cause of MSA is unknown but it is believed to be related to an accumulation of proteins in certain areas of the brain which leads to nerve cell death [7][8][9][10].

[1]: Multiple system atrophy (MSA) - Symptoms and causes - Mayo Clinic (
[2]: Multiple System Atrophy Fact Sheet | National Institute of ... (
[3]: What is Multiple System Atrophy?| MSA Symptoms & Treatment ... (
[4]: Multiple System Atrophy (MSA): Symptoms & Treatment (
[5]: Multiple system atrophy - NHS (
[6]: Multiple System Atrophy (MSA) - Symptoms and Causes (
[7]: Multiple system atrophy: MedlinePlus Genetics (
[8]: Multiple system atrophy - Wikipedia (
[9]: Multiple System Atrophy - National Organization for Rare Disorders (
[10]: Multiple System Atrophy: Practice Essentials, Background, Etiology ... (


Multiple system atrophy (MSA) is a rare, progressive neurological disorder that affects the brain and spinal cord. It is characterized by a combination of symptoms including muscle weakness, poor coordination, balance problems, slurred speech, difficulty swallowing and bladder control issues. MSA can also cause cognitive decline and dementia in some cases. There is currently no cure for MSA but treatments are available to help manage symptoms and slow progression of the disease.