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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is often associated with Irritable Bowel Syndrome (IBS), with reports of 50-90% of ME/CFS patients experiencing IBS symptoms such as diarrhea, nausea, gas and abdominal pain [1][2][3]. Studies have found an imbalance in the gut bacteria in individuals with ME/CFS and IBS [4], which may be linked to fecal metagenomic profiles in subgroups of patients with myalgic encephalomyelitis/chronic fatigue syndrome [5]. The emerging role of gut microbiota in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome suggests that it plays a role in the pathogenesis of this condition [6].

[1]: Gut inflammation in chronic fatigue syndrome - PMC (
[2]: The Link Between Irritable Bowel and Chronic Fatigue Syndrome ... (
[3]: Irritable bowel syndrome - MEpedia (
[4]: Link Found for Chronic Fatigue Syndrome | Columbia Public Health (
[5]: Fecal metagenomic profiles in subgroups of patients with myalgic ... (
[6]: The Emerging Role of Gut Microbiota in Myalgic Encephalomyelitis ... (


ME/CFS and IBS are both chronic illnesses that can cause a range of symptoms, including fatigue, pain, digestive issues, cognitive difficulties and more. While the exact causes of these conditions remain unknown, research suggests that they may be linked to an underlying immune system dysfunction or dysregulation. Treatment for ME/CFS and IBS often involves lifestyle modifications such as diet changes, stress management techniques and exercise regimens. Additionally, medications may be prescribed to help manage specific symptoms associated with each condition.