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IgA nephropathy (IgAN), also known as Berger's disease, is a kidney disease that occurs when an antibody called immunoglobulin A (IgA) deposits build up in the kidneys, causing inflammation [1][2]. This inflammation can cause the kidneys to leak blood and protein into the urine [3]. IgAN affects 20-40% of people who have it and can lead to end-stage kidney disease [4]. Treatment for IgAN includes medications such as ACE inhibitors or angiotensin receptor blockers, corticosteroids, immunosuppressants, and biologics. Prognosis depends on factors such as age at diagnosis, degree of proteinuria reduction after treatment initiation, and presence of hypertension [5][6][7]. It is also associated with other autoimmune diseases such as lupus nephritis [8] and has been studied in clinical trials using proteinuria reduction as a surrogate endpoint for evaluating treatments[9].

[1]: IgA nephropathy (Berger's disease) - Symptoms and causes - Mayo ... (
[2]: IgA Nephropathy | NIDDK (
[3]: IgA Nephropathy (Berger's Disease) - Symptoms, causes, diagnosis ... (
[4]: IGA Nephropathy Foundation of America (
[5]: IgA nephropathy: Treatment and prognosis - UpToDate (
[6]: Evaluating a New International Risk-Prediction Tool in IgA ... (
[7]: IgA Nephropathy - National Organization for Rare Disorders (
[8]: Study of Ravulizumab in Proliferative Lupus Nephritis (LN) or ... (
[9]: Proteinuria Reduction as a Surrogate End Point in Trials of IgA ... (


IgA nephropathy (IgAN) is a type of glomerulonephritis, which is an inflammation of the kidney's filtering units (glomeruli). It occurs when immunoglobulin A (IgA), an antibody normally found in the blood and other body fluids, builds up in the kidneys. This can cause damage to the glomeruli and lead to proteinuria (protein in urine), hematuria (blood in urine), hypertension, and eventually kidney failure. Treatment for IgAN typically involves medications such as ACE inhibitors or angiotensin receptor blockers to reduce blood pressure and slow down progression of disease. Other treatments may include corticosteroids or immunosuppressants to reduce inflammation, diuretics to help remove excess fluid from the body, and dietary changes such as reducing salt intake.