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Functional constipation, also known as chronic idiopathic constipation (CIC), is a type of functional bowel disorder characterized by difficult, infrequent, and/or incomplete defecation [1][2]. It is defined by criteria that include infrequent, hard, and/or large stools; fecal incontinence; abdominal pain or discomfort; bloating; straining during defecation; feeling of incomplete evacuation after defecation [3]. Diagnostic workup must not show any sign of abnormality to be diagnosed with functional constipation [7]. Symptoms may include spending a lot of time on the toilet straining and pushing to move your bowels, using fingers to get stool out [8], abdominal pain or discomfort, bloating[4], straining during defecation[5] and feeling of incomplete evacuation after defecation[6]. Prucalopride is a selective serotonin receptor agonist that can be used to treat chronic constipation [10]. AbbVie has submitted supplemental new drug application for prucalopride in pediatric patients with irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC)[9].


[1]: Chronic Idiopathic Constipation in Adults: A Review on Current ... (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547593/)
[2]: Chronic Idiopathic Constipation (https://ada.com/conditions/chronic-idiopathic-constipation/)
[3]: Chronic functional constipation and fecal incontinence in infants ... (https://www.uptodate.com/contents/chronic-functional-constipation-and-fecal-incontinence-in-infants-children-and-adolescents-treatment)
[4]: Update on the Management of Chronic Idiopathic Constipation (https://www.ajmc.com/view/update-on-the-management-of-chronic-idiopathic-constipati)
[5]: Chronic Functional Constipation With No Specific Cause (https://www.verywellhealth.com/functional-constipation-1945046)
[6]: Functional constipation - Wikipedia (https://en.wikipedia.org/wiki/Functional_constipation)
[7]: Chronic Idiopathic Constipation: Symptoms, Treatment, & Diet (https://www.verywellhealth.com/chronic-idiopathic-constipation-1944861)
[8]: Gut Check: What's Functional Constipation? (https://www.webmd.com/digestive-disorders/functional-constipation-explained)
[9]: AbbVie Submits Supplemental New Drug Application to U.S. FDA to ... (https://news.abbvie.com/news/press-releases/abbvie-submits-supplemental-new-drug-application-to-us-fda-to-support-new-indication-linzess-linaclotide-for-functional-constipation-in-children-and-adolescents-6-to-17-years-age.htm)
[10]: Role of Prucalopride in Treating Functional Constipation and ... (https://pubmed.ncbi.nlm.nih.gov/33968518/)

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Functional constipation, also known as chronic idiopathic constipation (CIC), is a common condition characterized by infrequent bowel movements and difficulty passing stools. It is usually caused by changes in diet or lifestyle, such as not eating enough fiber or drinking enough fluids. Treatment typically involves dietary modifications, increased physical activity, and medications to help stimulate the bowels. In some cases, psychological counseling may be recommended to address any underlying emotional issues that may be contributing to the problem.