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Chronic Lyme is a poorly defined term that describes the attribution of various atypical syndromes to protracted Borrelia burgdorferi infection [1]. Symptoms can include pain, fatigue, headaches and neck stiffness, facial palsy (loss of muscle tone or droop on one or both sides of the face) [2], and additional EM rashes on other areas of the body [2]. In Europe, Chronic Lyme may also cause a skin condition called acrodermatitis chronic atrophicans [4]. If left untreated, spirochetes can spread and go into hiding in different parts of the body causing long-term symptoms such as persistent pain and fatigue which are often referred to as "Chronic Lyme Disease" [3][5][6][7]. The International Lyme And Associated Diseases Society (ILADS) has proposed an evidence-based definition for Chronic Lyme Disease which includes criteria for diagnosis based on clinical presentation and laboratory testing[8].

[1]: Chronic Lyme Disease - PMC (
[2]: Signs and Symptoms of Untreated Lyme Disease | Lyme Disease ... (
[3]: Chronic Symptoms | Lyme Disease (
[4]: Lyme disease - Symptoms and causes - Mayo Clinic (
[5]: Chronic Lyme Disease can make patients profoundly debilitated. (
[6]: Chronic Lyme disease - Wikipedia (
[7]: A Critical Appraisal of “Chronic Lyme Disease” | NEJM (
[8]: Chronic Lyme Disease: An Evidence-Based Definition by the ILADS ... (


Chronic Lyme is a condition caused by the bacteria Borrelia burgdorferi, which is spread through the bite of an infected tick. Symptoms can include fatigue, joint pain, headaches, and cognitive difficulties. Treatment typically involves antibiotics to kill the bacteria and reduce symptoms. In some cases, additional treatments such as physical therapy or lifestyle changes may be recommended to help manage symptoms.